Repair of Interstrand Crosslinks
| PAG Title | Repair of Interstrand Crosslinks |
| PAG ID | WIG001822 |
| Type | P |
| Source Link |  Spike |
| Publication Reference | NA |
| PAG Description | Multiple pathways of DNA repair participate in the repair of DNA interstrand cross-links (ICLs). The major pathway is homologous recombination (HR) with involvement of the Fanconi anemia/BRCA proteins. Components of the nucleotide excision repair (NER) and mismatch repair (MMR), has cardinal roles in ICLs-sensing, signaling, and repair processes. Trans-lesion synthesis (TLS) by various error prone DNA polymerases contributes also to the ICLs damage resolution. |
| Species | Homo sapiens |
| nCoCo Score | 5,740 |
| Base PAG ID | WIG001822 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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